Article

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

2023-05-05

Abstract excerpt

<h4>SUMMARY</h4> Oct4 is a pioneer transcription factor regulating pluripotency. However, it is poorly known whether Oct4 has an impact on epidermal cells. We generated OCT4 knockout clonal cell lines using immortalized human skin keratinocytes to identify a functional role for the protein. Here we report that Oct4-deficient cells transitioned into a mesenchymal-like phenotype with enlarged size and shape, exhib...

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Literature Corpus work: e7e22127-4dbd-52c6-aad5-ca042d0f69ea
DOI: 10.1101/2023.05.05.539557

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