Article

Histone H1.0 Couples Cellular Mechanical Behaviors to Chromatin Structure

2022-12-01

Abstract excerpt

<h4>Summary</h4> Tuning of genome structure and function is accomplished by chromatin binding proteins, which determine the transcriptome and phenotype of the cell. We sought to investigate how communication between extracellular stress and chromatin structure may regulate cellular mechanical behaviors. We demonstrate that the linker histone H1.0, which compacts nucleosomes into higher order chromatin fibers, con...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7d0d0c3-79ca-5f90-9bd4-c17ebea4bc04
DOI: 10.1101/2022.11.29.518399

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Histone H1.0 Couples Cellular Mechanical Behaviors to Chromatin StructureDOI 10.1101/2022.11.29.518399Read

Intra-Nuclear Tensile Strain Mediates Reorganization of Epigenetically Marked Chromatin During Cardiac Development and DiseaseSemantic proximity Read

The dynamics of histone H1 function in chromatin.Semantic proximity Read

Histone H1 null vertebrate cells exhibit altered nucleosome architecture.Semantic proximity Read

Histone H1 diversity: bridging regulatory signals to linker histone function.Semantic proximity Read

PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosisSemantic proximity Read

The missing linker: emerging trends for H1 variant-specific functions.Semantic proximity Read

Epigenetic Regulation of Myogenesis: Focus on the Histone Variants.Semantic proximity Read

Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.Semantic proximity Read

PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosisSemantic proximity Read

Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presenceSemantic proximity Read

Histone variants and transcription regulation.Semantic proximity Read

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution ImagingSemantic proximity Read