Article

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

2021-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying inflammatory reactive astrocyte phenotypes remains under-explored. Here, we used CRISPR-based screening in human iPSC-derived astrocytes to identify mTOR activa...

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Literature Corpus work: b4d13419-dac5-5c79-8dde-25a48408134c
DOI: 10.1101/2021.09.11.459904

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