Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-33 Regulates the Phenotypic Transformation of Reactive Astrocytes via PENK-ERK/MAPK Pathway in Parkinson's Disease.

Neuroscience bulletin - 1 Jul 2026

Qu Yi, Mao Zhijuan, Wang Danlei, An Ke, Yu Haoheng, Qin Qixiong, Li Jingyi, Xiong Yongjie, Min Zhe, Xue Zheng

Abstract excerpt

Interleukin-33 (IL-33) regulates immune responses in central nervous system diseases. This study investigates the effect of IL-33 on astrocyte phenotypic transformation in Parkinson's disease (PD). The associations of IL-33, soluble growth-stimulating expression gene 2 (sST2), with PD severity and clinical symptoms were examined. IL-33 supplementation and knockdown were applied in vivo and in vitro to assess...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Enkephalins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-33

Share to MAP Kinase Signaling System

Share to Mice, Inbred C57BL

Share to Parkinson Disease

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41483148
DOI: 10.1007/s12264-025-01566-2
PMCID: PMC13388577

Genes

PENK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-33 Regulates the Phenotypic Transformation of Reactive Astrocytes via PENK-ERK/MAPK Pathway in Parkinson's Disease.PMID 41483148Read ↗

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson’s disease by targeting receptor interleukin-6Semantic proximity Read ↗

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytesSemantic proximity Read ↗

A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's diseaseSemantic proximity Read ↗

CD4+ T cell-associated cytokines induce a chronic pro-inflammatory phenotype in induced pluripotent stem cell-derived midbrain astrocytes.Semantic proximity Read ↗

PINK1 loss in astrocytes triggers inflammatory dysfunction and neuronal deathSemantic proximity Read ↗

Astrocytic ACSBG1 depletion improves lipid-cytokine signaling and attenuates α-Synuclein pathology in a Parkinson’s disease mouse modelSemantic proximity Read ↗

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signalingSemantic proximity Read ↗

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes.Semantic proximity Read ↗

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive statesSemantic proximity Read ↗

IFNγ alters the aberrant phenotype of α-synuclein-treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons.Semantic proximity Read ↗

Critical Roles of IL-33/ST2 Pathway in Neurological DisordersSemantic proximity Read ↗

Varicose-projection astrocytes: a reactive phenotype associated with neuropathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.