Article

Differential stimulation of pluripotent stem cell-derived human microglia leads to exosomal proteomic changes affecting neurons

2021-07-20

Abstract excerpt

Microglial exosomes are an emerging communication pathway, implicated in fulfilling homeostatic microglial functions and transmitting neurodegenerative signals. Gene variants of the triggering receptor expressed myeloid cells-2 (TREM2) are associated with an increased risk of developing dementia. We investigated the influence of the TREM2 Alzheimer’s disease risk variant, R47H het , on the microglial exosomal p...

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Literature Corpus work: 2016c46e-c8e9-5660-9c28-c593ac1ae1b7
DOI: 10.1101/2021.07.19.452610

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