Article

Development of a <i>De Novo</i> Protein Binder that Inhibits the Alpha Kinase eEF2K

2024-12-11

Abstract excerpt

<h4>SUMMARY</h4> Elongation factor 2 kinase (eEF2K) is calmodulin activated and phosphorylates eEF2, a GTPase, that regulates global translation. When eEF2K phosphorylates eEF2, protein translation is halted. This process may be critical to studying how diseases like cancer dysregulate protein synthesis. eEF2K is an alpha kinase and not targeted by conventional kinase inhibitors. Traditional methods of structure-...

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Literature Corpus work: b4ba8a82-20cd-5e7d-ba08-021ee6fd164e
DOI: 10.1101/2024.12.10.627789

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