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Target-driven design of a coumarinyl chalcone scaffold based novel EF2 Kinase inhibitor suppresses breast cancer growth <i>in vivo</i>

2020-11-08

Abstract excerpt

Eukaryotic elongation factor 2 kinase (eEF-2K), an unusual alpha kinase, is involved in protein synthesis through phosphorylation of elongation factor 2 (EF2). eEF-2K is indicated as one of the critical drivers of breast cancer and associated with poor clinical prognosis, representing a potential molecular target. The crystal structure of eEF-2K is unknown and there is no potent and effective eEF-2K inhibitor repo...

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Identifiers and source

Literature Corpus work
5906f278-a911-5f6e-a0ae-058591db1d8b
DOI
10.1101/2020.11.06.371062
Open publication

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