Article

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

2024-01-10

Abstract excerpt

<h4>Summary</h4> Despite the well-established significance of transcription factors (TFs) in pathogenesis, their utilization as pharmacological targets has been limited by the inherent challenges associated with modulating their protein-protein and protein-DNA interactions. The lack of defined small-molecule binding pockets and the nuclear localization of TFs do not favor the use of small-molecule inhibitors, or...

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Literature Corpus work: 3fb93d44-43f3-5bc3-ac2f-cae57e3ba4b7
DOI: 10.1101/2024.01.09.574928

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