Article

Computer-guided Binding Mode Identification and Affinity Improvement of an LRR Protein Binder without Structure Determination

2019-12-19

Abstract excerpt

Precise binding mode identification and subsequent affinity improvement without structure determination remain a challenge in the development of therapeutic proteins. However, relevant experimental techniques are generally quite costly, and purely computational methods have been unreliable. Here, we show that integrated computational and experimental epitope localization followed by full-atom energy minimization c...

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Literature Corpus work: 0acfde0d-7659-53dc-b381-def3496245fd
DOI: 10.1101/2019.12.18.880534

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Computer-guided Binding Mode Identification and Affinity Improvement of an LRR Protein Binder without Structure DeterminationDOI 10.1101/2019.12.18.880534Read

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