Article

Dynamic-Structure Redesign of Calmodulin Reveals Mechanistic Constraints on Ryr2 Regulation

2026-04-17

Abstract excerpt

2. <h4>ABSTRACT</h4> Calmodulin (CaM) is a highly conserved Ca 2+ sensor that regulates hundreds of cellular targets through Ca 2+ -dependent conformational dynamics. Despite its central role in Ca 2+ signaling and disease, its evolutionary conservation and structural flexibility have suggested that CaM is resistant to rational redesign. Here, using the cardiac Ca 2+ release channel Ryanodine receptor 2 (RyR2...

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Literature Corpus work: 869c8da6-933a-528f-ada9-2c6542350db1
DOI: 10.64898/2026.04.14.717973

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