Article

A GCN1-independent activator of the kinase GCN2

2025-07-03

Abstract excerpt

Mutations of EIF2AK4 , which encodes the eIF2α kinase GCN2, cause a severe inherited form of pulmonary hypertension called pulmonary veno-occlusive disease (PVOD). Some pathogenic variants of GCN2 are amenable to pharmacological reactivation by low concentrations of ATP-pocket binding inhibitors. Kinase inhibition at modestly elevated concentrations limits the clinical utility of these drugs against PVOD. We ther...

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Literature Corpus work: 078bf3d9-c427-5c6c-bbed-6852fe71dfdf
DOI: 10.1101/2025.06.29.662197

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