Article

Site-specific amino-acid preferences are mostly conserved in two closely related protein homologs

2015-04-23

Abstract excerpt

Evolution drives changes in a protein’s sequence over time. The extent to which these changes in sequence lead to shifts in the underlying preference for each amino acid at each site is an important question with implications for comparative sequence-analysis methods such as molecular phylogenetics. To quantify the extent that site-specific amino-acid preferences shift during evolution, we performed deep mutationa...

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Literature Corpus work: b4930aa7-4a82-5a45-842e-f3d5ac0cbcbc
DOI: 10.1101/018457

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