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Article

Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs.

Molecular biology and evolution - 1 Nov 2015

Doud Michael B, Ashenberg Orr, Bloom Jesse D

Abstract excerpt

Evolution drives changes in a protein's sequence over time. The extent to which these changes in sequence lead to shifts in the underlying preference for each amino acid at each site is an important question with implications for comparative sequence-analysis methods, such as molecular phylogenetics. To quantify the extent that site-specific amino acid preferences shift during evolution, we performed deep...

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Identifiers

PMID: 26226986
DOI: 10.1093/molbev/msv167
PMCID: PMC4626756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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