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Article

An evolutionary model motivated by physicochemical properties of amino acids reveals variation among proteins.

Bioinformatics (Oxford, England) - 1 Jul 2018

Braun Edward L

Abstract excerpt

Motivation: The relative rates of amino acid interchanges over evolutionary time are likely to vary among proteins. Variation in those rates has the potential to reveal information about constraints on proteins. However, the most straightforward model that could be used to estimate relative rates of amino acid substitution is parameter-rich and it is therefore impractical to use for this purpose. Results: A...

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PMID: 29950007
DOI: 10.1093/bioinformatics/bty261
PMCID: PMC6022633

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PAM

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Source receipt: pubmed, retrieved 7 Sept 2026.

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