Article

Evolutionary and Functional Lessons from Human-Specific Amino-Acid Substitution Matrices

2020-05-10

Abstract excerpt

The characterization of human genetic variation in coding regions is fundamental to our understanding of protein function, structure, and evolution. Amino-acid (AA) substitution matrices such as BLOSUM (BLOcks SUbstitution Matrix) and PAM (Point Accepted Mutations) encapsulate the stochastic nature of such proteomic variation and are used in studying protein families and evolutionary processes. However, these matr...

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Literature Corpus work: 7867d5f9-d9a5-5c9a-8a13-a9aa020c6281
DOI: 10.1101/2020.05.09.086009

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