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Article

Failure to replicate a genetic association may provide important clues about genetic architecture.

PloS one - 2 Jun 2009

Greene Casey S, Penrod Nadia M, Williams Scott M, Moore Jason H

Abstract excerpt

Replication has become the gold standard for assessing statistical results from genome-wide association studies. Unfortunately this replication requirement may cause real genetic effects to be missed. A real result can fail to replicate for numerous reasons including inadequate sample size or variability in phenotype definitions across independent samples. In genome-wide association studies the allele frequencies...

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Identifiers

PMID: 19503614
DOI: 10.1371/journal.pone.0005639
PMCID: PMC2685469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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