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Article

Statistical correction of the Winner's Curse explains replication variability in quantitative trait genome-wide association studies.

PLoS genetics - 1 Jul 2017

Palmer Cameron, Pe'er Itsik

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery cohorts. This limited success of replication raises pervasive questions about the utility of the GWAS field. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28715421
DOI: 10.1371/journal.pgen.1006916
PMCID: PMC5536394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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