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Article

Accurate modeling of replication rates in genome-wide association studies by accounting for Winner's Curse and study-specific heterogeneity.

G3 (Bethesda, Md.) - 1 Dec 2022

Zou Jennifer, Zhou Jinjing, Faller Sarah, Brown Robert P, Sankararaman Sriram S, Eskin Eleazar

Abstract excerpt

Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human traits, but only a fraction of variants identified in discovery studies achieve significance in replication studies. Replication in genome-wide association studies has been well-studied in the context of Winner's Curse, which is the inflation of effect size estimates for significant variants due to...

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PMID: 36250793
DOI: 10.1093/g3journal/jkac261
PMCID: PMC9713380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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