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Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses

2024-03-27

Abstract excerpt

Immune reactions to protein drugs present substantial challenges to protein replacement for treating congenital diseases and metabolic deficiencies, due to the lack of endogenous tolerance or the protein drug’s partial or total non-human origin. We sought to transiently modify the immune environment when the adaptive response to the drug antigen is mounted to lessen future reactions upon continued therapeutic trea...

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Identifiers and source

Literature Corpus work
b46e7e09-144f-574f-960e-8a5f402f3149
DOI
10.1101/2024.03.21.586168
Open publication

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Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody ResponsesDOI 10.1101/2024.03.21.586168
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