Article

De novo masking domains that gate TNF-family ligand assembly and activity

2026-04-22

Abstract excerpt

Tumor necrosis factor family ligands (TNFLs) are central regulators of immunity and promising agents for cancer therapy, but their clinical use is often limited by dose-limiting systemic toxicity. Conditional activation and genetic fusion with antibodies could improve safety and pharmacokinetics, yet these features are difficult to combine because TNFLs form obligate homotrimers that are structurally mismatched wi...

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Literature Corpus work: 6df67731-c41c-51cb-adcf-111dd986b31c
DOI: 10.64898/2026.04.20.719557

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