Article
A Review of Alpha-1 Antitrypsin Binding Partners for Immune Regulation and Potential Therapeutic Application.
International journal of molecular sciences - 23 Feb 2022
O'Brien Michael E, Murray Grace, Gogoi Debananda, Yusuf Azeez, McCarthy Cormac, Wormald Mark R, Casey Michelle, Gabillard-Lefort Claudie, McElvaney Noel G, Reeves Emer P
Abstract excerpt
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived proteases and can modulate innate immune mechanisms through its anti-inflammatory activities mediated by a broad spectrum of protein, cytokine, and cell surface interactions. AAT contains a reactive methionine residue that is critical for its protease-specific binding capacity, whereby AAT entraps the protease on cleavage...
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