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Article

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.

Journal of autoimmunity - 1 Jan 2015

Bell Charles J M, Sun Yongliang, Nowak Urszula M, Clark Jan, Howlett Sarah, Pekalski Marcin L, Yang Xin, Ast Oliver, Waldhauer Inja, Freimoser-Grundschober Anne, Moessner Ekkehard, Umana Pablo, Klein Christian, Hosse Ralf J, Wicker Linda S, Peterson Laurence B

Abstract excerpt

Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and are deficient in many common autoimmune diseases. Immune tolerance is maintained in part by IL-2 and deficiencies in the IL-2 pathway cause reduced Treg function and an increased risk of autoimmunity. Recent studies expanding Tregs in vivo with low-dose IL-2 achieved major clinical successes highlighting the...

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Source

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Identifiers

PMID: 25457307
DOI: 10.1016/j.jaut.2014.10.002
PMCID: PMC4298360

Genes

FOXP3
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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