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Article

Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion.

PloS one - 1 Jan 2017

Levin Itay, Zaretsky Marianna, Aharoni Amir

Abstract excerpt

TNF-like 1A (TL1A) is a cytokine belonging to the TNF superfamily that promotes inflammation in autoimmune diseases. Inhibiting the interaction of TL1A with the endogenous death-domain receptor 3 (DR3) offers a therapeutic approach for treating TL1A-induced autoimmune diseases. Here, we generated improved DR3 variants showing increased TL1A binding affinity and stability using a directed evolution approach. Given...

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Identifiers

PMID: 28278297
DOI: 10.1371/journal.pone.0173460
PMCID: PMC5344418

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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