Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression.

Trends in genetics : TIG - 1 Aug 2018

Hou Jing, van Leeuwen Jolanda, Andrews Brenda J, Boone Charles

Abstract excerpt

The phenotypic consequences of a given mutation can vary across individuals. This so-called background effect is widely observed, from mutant fitness of loss-of-function variants in model organisms to variable disease penetrance and expressivity in humans; however, the underlying genetic basis often remains unclear. Taking insights gained from recent large-scale surveys of genetic interaction and suppression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epistasis, Genetic
Share to Evolution, Molecular
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Background

Share to Genetics, Population

Share to Quantitative Trait, Heritable

Share to Quantitative Trait Loci

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 29903533
DOI: 10.1016/j.tig.2018.05.006
PMCID: PMC6085889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Network Complexity Shapes Background-Dependent Phenotypic Expression.PMID 29903533Read ↗

The complex role of genetic background in shaping the effects of spontaneous and induced mutations.Semantic proximity Read ↗

Genetic background effects in quantitative genetics: gene-by-system interactions.Semantic proximity Read ↗

Population-level survey of loss-of-function mutations revealed that background dependent fitness genes are rare and functionally related in yeastSemantic proximity Read ↗

Loss-of-function mutation survey revealed that genes with background-dependent fitness are rare and functionally related in yeast.Semantic proximity Read ↗

The impact of the genetic background on gene deletion phenotypes in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Causes and consequences of genetic background effects illuminated by integrative genomic analysis.Semantic proximity Read ↗

The Hidden Complexity of Mendelian Traits across Natural Yeast Populations.Semantic proximity Read ↗

The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The conditional nature of genetic interactions: the consequences of wild-type backgrounds on mutational interactions in a genome-wide modifier screen.Semantic proximity Read ↗

Genetic interaction networks: toward an understanding of heritability.Semantic proximity Read ↗

The modifiers that cause changes in gene essentialitySemantic proximity Read ↗

The modifiers that cause changes in gene essentiality.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.