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USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction

14 Apr 2022

Abstract excerpt

TNF receptor-associated factor 6 (TRAF6)-BECN1 signaling axis plays a pivotal role in autophagy induction through ubiquitination of BECN1, thereby inducing lung cancer migration and invasion in response to toll-like receptor 4 (TLR4) stimulation. Herein, we provide novel molecular and cellular mechanisms involved in the negative effect of ubiquitin-specific peptidase 15 (USP15) on lung cancer progression....

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PMID: 35422093
DOI: 10.1038/s41419-022-04808-7

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