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Assessing the prediction of type 2 diabetes risk using polygenic and clinical risk scores in South Asian study populations

1 Jan 2023

Abstract excerpt

Background: Genome-wide polygenic risk scores (PRS) have shown high specificity and sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven information and its clinical significance in non-Europeans are underrepresented. We examined the predictive efficacy and transferability of PRS models using variant information derived from genome-wide studies of Asian Indians (AIs) (PRS AI...

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PMID: 38152657
DOI: 10.1177/20420188231220120

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