Article
Utility of genetic risk scores in type 1 diabetes.
Diabetologia - 1 Sept 2023
Luckett Amber M, Weedon Michael N, Hawkes Gareth, Leslie R David, Oram Richard A, Grant Struan F A
Abstract excerpt
Iterative advances in understanding of the genetics of type 1 diabetes have identified >70 genetic regions associated with risk of the disease, including strong associations across the HLA class II region that account for >50% of heritability. The increased availability of genetic data combined with the decreased costs of generating these data, have facilitated the development of polygenic scores that aggregate...
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