Article

Fine-mapping of <i>SNCA</i> in REM sleep behavior disorder and overt synucleinopathies

2019-09-04

Abstract excerpt

<h4>Objective</h4> REM-sleep behavior disorder (RBD) is a prodromal synucleinopathy, as >80% will eventually convert to overt synucleinopathy. We performed an in-depth analysis of the SNCA locus to identify RBD-specific risk variants. <h4>Methods</h4> Full sequencing and genotyping of SNCA was performed in isolated/idiopathic RBD (iRBD, n=1,076), Parkinson’s disease (PD, n=1,013), and dementia with Lewy bodie...

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Literature Corpus work: 4236076b-1567-5c0c-8e82-ccf1f6594835
DOI: 10.1101/756528

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