Article

Global Effects of a PD Risk-SNP at the Alpha-Synuclein Locus

2021-07-08

Abstract excerpt

<h4>SUMMARY</h4> One of the most significant Parkinson’s disease (PD) risk variants, rs356182, is located at the PD-associated locus near the alpha-synuclein encoding gene, SNCA . SNCA -proximal variants, including rs356182, are thought to function in PD via allele-specific regulatory effects on SNCA expression. However, this interpretation discounts the complex activity of genetic enhancers and possible noncon...

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Literature Corpus work: 2995a65d-e31f-50dd-b688-5eec4dad4da3
DOI: 10.1101/2021.07.06.451330

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