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Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease

11 Jan 2021

Abstract excerpt

Epigenetic deregulation of α-synuclein plays a key role in Parkinson's disease (PD). Analysis of the SNCA promoter using the ENCODE database revealed the presence of important histone post-translational modifications (PTMs) including transcription-promoting marks, H3K4me3 and H3K27ac, and repressive mark, H3K27me3. We investigated these histone marks in post-mortem brains of controls and PD patients and observed...

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PMID: 33428332
DOI: 10.15252/emmm.202012188

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