Article

The diversity of <i>SNCA</i> transcripts in neurons, and its impact on antisense oligonucleotide therapeutics

2024-05-31

Abstract excerpt

<h4>Summary</h4> The role of the SNCA gene locus in driving Parkinson’s disease (PD) through rare and common genetic variation is well-recognized, but the transcriptional diversity of SNCA in vulnerable cell types remains unclear. We performed SNCA long-read RNA sequencing in human dopaminergic neurons and show that annotated SNCA transcripts account for only 5% of expression. Rather, the majority of expressi...

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Literature Corpus work: 2dfed1ab-b150-56aa-a4b8-4dcf973368b9
DOI: 10.1101/2024.05.30.596437

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