Article

Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronaviruses

2021-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Three pathogenic human coronaviruses have emerged within the last 20 years, with SARS-CoV-2 causing a global pandemic. Although therapeutic antibodies targeting the SARS-CoV-2 spike currently focus on the poorly conserved receptor-binding domain, targeting essential neutralizing epitopes on the more conserved S2 domain may provide broader protection. We report an antibody binding an epitope cons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3094a18f-d57e-5a1d-93bd-40310e5b88b0
DOI: 10.1101/2021.01.31.428824

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of a conserved neutralizing epitope present on spike proteins from all highly pathogenic coronavirusesDOI 10.1101/2021.01.31.428824Read

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronavirusesSemantic proximity Read

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read

The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopesSemantic proximity Read

Structural Insights into the SARS-CoV-2 Spike Protein and Its Implications for Antibody Resistance.Semantic proximity Read

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of ConcernSemantic proximity Read

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodiesSemantic proximity Read

Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformationSemantic proximity Read

Defining the Antigenic Topology and Prospective Binding Breadth of Vaccination-induced SARS-CoV-2 Neutralizing AntibodiesSemantic proximity Read

Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteinsSemantic proximity Read

SARS-CoV-2 spike S2-specific neutralizing antibodiesSemantic proximity Read

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its baseSemantic proximity Read

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodiesSemantic proximity Read