Article

Sp1 mechanotransduction regulates breast cancer cell invasion in response to multiple tumor-mimicking extracellular matrix cues

2025-03-19

Abstract excerpt

Breast cancer progression is marked by extracellular matrix (ECM) remodeling, including increased stiffness, faster stress relaxation, and elevated collagen levels. In vitro experiments have revealed a role for each of these factors to individually promote malignant behavior, but their combined effects remain unclear. To address this, we developed alginate-collagen hydrogels with independently tunable stiffness, s...

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Literature Corpus work: b3c2492b-ffda-550a-86e4-cf8161f5f15c
DOI: 10.1101/2025.03.18.643983

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