Article

Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity

2025-10-24

Abstract excerpt

Invasion plasticity allows malignant cells to toggle between collective, mesenchymal and amoeboid phenotypes while traversing extracellular matrix (ECM) barriers. Current dogma holds that collective and mesenchymal invasion programs trigger the mobilization of proteinases that digest structural barriers dominated by type I collagen, while amoeboid activity allows cancer cells to marshal mechanical forces to traver...

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Identifiers and source

Literature Corpus work: 90c187e4-74c5-5499-9b0f-b1a73526fff6
DOI: 10.1101/2025.10.24.684403

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