Article

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

2021-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Rhes ( RASD2 ) is a thyroid hormone-induced gene that regulates striatal motor activity and promotes neurodegeneration in Huntington disease (HD) and tauopathy. Previously, we showed that Rhes moves between cultured striatal neurons and transports the HD protein, polyglutamine-expanded huntingtin (mHTT) via tunneling nanotube (TNT)-like membranous protrusions. However, similar intercellular Rhe...

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Literature Corpus work: b3a9d737-0c27-523b-bd65-d7dc59a3b0a6
DOI: 10.1101/2021.08.27.457956

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