Article

Farnesyl Transferase Inhibition for the Treatment of Tauopathies

2018-12-18

Abstract excerpt

Tau inclusions are a shared feature of many neurodegenerative conditions and tau mutations lead to frontotemporal dementia. Approaches to treatment of these conditions have focused directly on the tau protein by targeting its post-translational modifications, its levels and its tendency to aggregate. We discovered a novel regulatory pathway for tau degradation that operates through the Rhes protein, a GTPase. Rhes...

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Identifiers and source

Literature Corpus work: 349089c5-6777-51e2-8328-c168e93a1324
DOI: 10.1101/500801

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