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Article

Global Rhes knockout in the Q175 Huntington's disease mouse model.

PloS one - 1 Jan 2021

Heikkinen Taneli, Bragge Timo, Kuosmanen Juha, Parkkari Teija, Gustafsson Sanna, Kwan Mei, Beltran Jose, Ghavami Afshin, Subramaniam Srinivasa, Shahani Neelam, Ramírez-Jarquín Uri Nimrod, Park Larry, Muñoz-Sanjuán Ignacio, Marchionini Deanna M

Abstract excerpt

Huntington's disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-binding protein highly expressed in the striatum that has been reported to modulate mTOR and sumoylation of mutant huntingtin to alter HD mouse model pathogenesis. Reports...

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Identifiers

PMID: 34648564
DOI: 10.1371/journal.pone.0258486
PMCID: PMC8516231

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