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Article

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.

Nature neuroscience - 18 Dec 2011

Subramaniam Srinivasa, Napolitano Francesco, Mealer Robert G, Kim Seyun, Errico Francesco, Barrow Roxanne, Shahani Neelam, Tyagi Richa, Snyder Solomon H, Usiello Alessandro

Abstract excerpt

L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes(-/-) mice showed reduced striatal mTOR signaling and diminished dyskinesia, but maintained motor...

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PMID: 22179112
DOI: 10.1038/nn.2994
PMCID: PMC3267880

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Source receipt: pubmed, retrieved 7 Sept 2026.

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