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Article

Rhes suppression enhances disease phenotypes in Huntington's disease mice.

Journal of Huntington's disease - 1 Jan 2014

Lee John H, Sowada Matthew J, Boudreau Ryan L, Aerts Andrea M, Thedens Daniel R, Nopoulos Peg, Davidson Beverly L

Abstract excerpt

In Huntington's disease (HD) mutant HTT is ubiquitously expressed yet the striatum undergoes profound early degeneration. Cell culture studies suggest that a striatal-enriched protein, Rhes, may account for this vulnerability. We investigated the therapeutic potential of silencing Rhes in vivo using inhibitory RNAs (miRhes). While Rhes suppression was tolerated in wildtype mice, it failed to improve rotarod...

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Source

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Identifiers

PMID: 25062765
DOI: 10.3233/JHD-140094
PMCID: PMC4139702

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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