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Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route

19 Jul 2022

Abstract excerpt

The CAG/CAA expansion encoding polyQ huntingtin (mutant huntingtin [mHTT]) causes Huntington's disease (HD), which is characterized by atrophy and loss of striatal medium spiny neurons (MSNs), which are preceded by neuropathological alterations in the cortex. Previous studies have shown that mHTT can spread in the brain, but the mechanisms involved in the stereotyped degeneration and dysfunction of the neurons...

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PMID: 35871361
DOI: 10.3233/jhd-220548

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