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Article

Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread.

Science advances - 20 Mar 2026

Dagar Sunayana, Fernandez Alexandra, Ramírez-Jarquín Uri Nimrod, Lopez-Huerta Violeta Gisselle, Mirza Emaad, Mohapatra Chinmayee, Zuniga Isabella, Urban Nicolai T, Crynen Gogce, Tsaprailis George, Subramaniam Srinivasa

Abstract excerpt

Tunneling nanotubes (TNTs) are membranous structures that mediate intercellular transfer of proteins, including the pathogenic mutant Huntingtin (mHTT) protein in Huntington disease (HD). We previously identified the ras homolog enriched in the striatum (Rhes) as a key regulator of TNT formation and mHTT transmission; however, the molecular components underlying this process remained unknown. Here, using unbiased...

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Identifiers

PMID: 41861004
DOI: 10.1126/sciadv.aea1226
PMCID: PMC13004034

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