Article

SpecImmune accurately genotypes diverse immune-related gene families using long-read data

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Polymorphic immune-related genes (HLA, KIR, IG, TCR, and CYP) exhibit significant complexity due to their extensive heterozygosity and inter-loci homology, necessitating specific methods for accurate characterization. We present SpecImmune, the first comprehensive tool leveraging long-read sequencing data to resolve the full spectrum of these immune-related genes. The method adopts an iterative...

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Literature Corpus work: b3a926db-3dcc-562f-91b4-951c1d13bfdf
DOI: 10.1101/2025.02.04.636381

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