Article

Graph-KIR: Graph-based KIR Copy Number Estimation and Allele Calling Using Short-read Sequencing Data

2023-12-01

Abstract excerpt

Motivation: The Killer-cell Immunoglobulin-like Receptor (KIR) is a highly polymorphic region in the human genome, associated with autoimmune diseases and organ transplantation. The sequences of KIR genes are highly similar among star alleles as well as in between individual genes, with the copy number of each KIR gene typically ranging from 0 to 4. In this study, we introduce a tool Graph-KIR that aims to estimat...

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Literature Corpus work: 39f7d07e-ce47-5492-a29c-bda004504787
DOI: 10.1101/2023.11.29.568665

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