Article

Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination

2024-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Homologous recombination (HR) and translesion synthesis (TLS) promote gap-filling DNA synthesis to complete genome replication. One factor involved in both pathways is RAD18, an E3 ubiquitin ligase. Although RAD18’s role in promoting TLS through the ubiquitination of PCNA at lysine 164 (K164) is well established, its requirement for HR-based mechanisms is currently less clear. To assess this, we...

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Literature Corpus work: b34e5346-672e-5b69-8d54-6273f1a5ca6e
DOI: 10.1101/2024.09.03.611050

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