Article

Differential roles of Rad18 in repressing carcinogen- and oncogene-driven mutagenesis <i>in vivo</i>

2025-07-04

Abstract excerpt

<h4>ABSTRACT</h4> The DNA repair protein RAD18 activates ‘Y-family’ Trans-Lesion Synthesis (TLS) DNA polymerases that are DNA damage-tolerant and potentially error-prone. RAD18 is also frequently overexpressed and pathologically activated in cancer cells. However, the extent to which RAD18 shapes cancer genomes and impacts tumorigenesis is unclear. Therefore, we tested the effect of Rad18 status on chemically-in...

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Literature Corpus work: edacfc3e-ef72-58a9-9cca-3abe75b7f029
DOI: 10.1101/2025.06.30.662411

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