Article

The Cancer Testes Antigen, HORMAD1, is a Tumor-Specific Replication Fork Protection Factor

2023-02-03

Abstract excerpt

<h4>SUMMARY</h4> Tumors frequently activate the expression of genes that are only otherwise required for meiosis. HORMAD1, which is essential for meiotic recombination in multiple species, is expressed in over 50% of human lung adenocarcinoma cells (LUAD). We previously found that HORMAD1 promotes DNA double strand break (DSB) repair in LUAD. Here, we report that HORMAD1 takes on an additional role in protecting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d255c1d-6f16-5093-876d-835fd9942dbd
DOI: 10.1101/2023.01.31.526348

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Cancer Testes Antigen, HORMAD1, is a Tumor-Specific Replication Fork Protection FactorDOI 10.1101/2023.01.31.526348Read

Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8–MCM9 complex and compromises DNA mismatch repair in cancer cellsSemantic proximity Read

MND1 enables repair of two-ended DNA double-strand breaksSemantic proximity Read

Genetic control of mitotic-to-meiotic transition regulates germline cell survivalSemantic proximity Read

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cellsSemantic proximity Read

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisSemantic proximity Read

Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress toleranceSemantic proximity Read

Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE SyndromeSemantic proximity Read

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.Semantic proximity Read

DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.Semantic proximity Read

The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapySemantic proximity Read

Identification of Novel Modulators of the ALT Pathway Through a Native FISH-Based Optical ScreenSemantic proximity Read

Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancerSemantic proximity Read