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RAD18 directs DNA double-strand break repair by homologous recombination to post-replicative chromatin

5 Jun 2024

Abstract excerpt

RAD18 is an E3 ubiquitin ligase that prevents replication fork collapse by promoting DNA translesion synthesis and template switching. Besides this classical role, RAD18 has been implicated in homologous recombination; however, this function is incompletely understood. Here, we show that RAD18 is recruited to DNA lesions by monoubiquitination of histone H2A at K15 and counteracts accumulation of 53BP1....

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PMID: 38884202
DOI: 10.1093/nar/gkae499

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