Article

Single cell atlas of trisomy 21 cerebral cortex

2020-01-02

Abstract excerpt

Down syndrome (DS) is one of the most common human birth defects caused by trisomy 21 (T21), leading to a variety of cognitive impairments. The cellular composition of human brain has been explored using single cell RNA sequencing in both physiological and pathological conditions. However, the cellular heterogeneity of human brain with chromosome aneuploidy is largely unknown. Here, we profiled the transcriptome o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1997c903-b81c-5cbe-b8de-839262715dea
DOI: 10.1101/2020.01.01.892398

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell atlas of trisomy 21 cerebral cortexDOI 10.1101/2020.01.01.892398Read

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortexSemantic proximity Read

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortexSemantic proximity Read

Single-cell atlas of the fetal Down syndrome cortex uncovers chromosome 21 regulators of intellectual disability gene networksSemantic proximity Read

A New Approach to The Pathogenesis of Down Syndrome: An Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21.Semantic proximity Read

Integrated Quantitative Neuro-transcriptome Analysis of Several Brain Areas in Human Trisomy 21Semantic proximity Read

Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular FunctionsSemantic proximity Read

Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cellsSemantic proximity Read

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndromeSemantic proximity Read

Deficits in human trisomy 21 iPSCs and neurons.Semantic proximity Read

Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21Semantic proximity Read

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndromeSemantic proximity Read

Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease.Semantic proximity Read