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Article

Altered cell and RNA isoform diversity in aging Down syndrome brains

18 Nov 2021

Abstract excerpt

Down syndrome (DS), trisomy of human chromosome 21 (HSA21), is characterized by lifelong cognitive impairments and the development of the neuropathological hallmarks of Alzheimer’s disease (AD). The cellular and molecular modifications responsible for these effects are not understood. Here we performed single-nucleus RNA sequencing (snRNA-seq) employing both short- (Illumina) and long-read (Pacific Biosciences)...

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PMID: 34795060
DOI: 10.1073/pnas.2114326118

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