Article

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortex

2025-07-04

Abstract excerpt

Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this disorder remain unclear, limited by a lack of systematic studies in the developing human brain. Here, we leveraged single-nucleus multi-omics to profile the mid-gestation neocortex in a cohort of 26 donors. We observed a re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9708958-6d6e-5661-a9e2-5704f977f829
DOI: 10.1101/2025.06.30.662136

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated in the developing Down syndrome neocortexDOI 10.1101/2025.06.30.662136Read

A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortexSemantic proximity Read

Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortexSemantic proximity Read

Single-cell atlas of the fetal Down syndrome cortex uncovers chromosome 21 regulators of intellectual disability gene networksSemantic proximity Read

Single cell atlas of trisomy 21 cerebral cortexSemantic proximity Read

Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brainsSemantic proximity Read

Single-cell analysis of prenatal and postnatal human cortical developmentSemantic proximity Read

Molecular Cartography of the Human and Mouse Down Syndrome BrainSemantic proximity Read

Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular FunctionsSemantic proximity Read

Single-cell multi-omics map of human fetal blood in Down syndrome.Semantic proximity Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read

Accelerated Tempo of Cortical Neurogenesis in Down SyndromeSemantic proximity Read

Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21Semantic proximity Read